The effect of alcohol on cancer development is a public health concern. Cancer and alcohol intake have a nearly linear association.
Alcohol has long been known to play a role in the development of numerous cancers, including pharyngeal, esophageal, colorectal, oral cavity, and breast cancer
The first metabolite formed after alcohol metabolism, acetaldehyde, is far more hazardous than the ethanol consumed.
Acetaldehyde, a carcinogen, is a highly reactive metabolite that binds to and impairs the function of a variety of components, including DNA and proteins.
Interference with DNA replication, for example, can cause irreversible damage and increase cancer growth.
In terms of cancer risk and incidence, the more acetaldehyde the body is exposed to, the more likely it is to acquire cancer.